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Total body irradiation

Total Body Irradiation (TBI) is a radiotherapy technique used to ablate the bone marrow and immune system prior to bone marrow transplantation or peripheral blood stem cell transplantation. It may be used as part of high-dose treatment of some leukaemias and lymphomas. The aim of this type of ablative therapy is to prevent rejection of the transplanted cells.

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During TBI the whole body is irradiated to between 9 to 14 Gy, a dose which, though modest by normal radiotherapy standards (when restricted to a small portion of the body, usually the tumor site) would be lethal when absorbed by the entire body if not directly followed by the transplant.

v • d • e Organ transplantation
Types	Allograft · Alloplant · Allotransplantation · Autotransplantation · Xenotransplantation
Organs and tissues	Bone · Bone marrow · Corneal · Face · Hand · Heart · Heart-lung · Kidney · Liver · Lung · Pancreas · Penis · Skin · Spleen · Uterus
Related topics	Biomedical tissue · Cellular memory · Edmonton protocol · Eye bank · Graft-versus-host disease · Immunosuppressive drugs · Islet cell transplantation · Implants · Living donor liver transplantation · Lung allocation score · Machine perfusion · Medical grafting · Non-heart beating donation · Organ donation · Post-transplant lymphoproliferative disorder · Total body irradiation · Transplant rejection
Organizations	Halachic Organ Donor Society · Human Tissue Authority · National Marrow Donor Program · United Network for Organ Sharing
People	Christiaan Barnard · Michael Woodruff · Alexis Carrel · Norman Shumway · Jean-Michel Dubernard · List of notable organ transplant donors and recipients