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For norepinephrine to be acted upon by PNMT in the cytosol, it must first be shipped out of granules of the chromaffin cells. This may occur via the catecholamine-H+ exchanger VMAT1.
Additional recommended knowledge
VMAT1 is also responsible for transporting newly synthesized epinephrine from the cytosol back into chromaffin granules in preparation for release.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "VMAT1". A list of authors is available in Wikipedia.|