Raman Rxn2 Analyzer with Rxn-46 Probe

Raman spectroscopy is an established key technology for the biopharmaceutical industry. It enables the non-destructive analysis of the molecular composition of a medium - without sampling and without preparation. This allows complex upstream and downstream processes to be monitored and controlled in real time. The scalable Raman solutions from Endress+Hauser support a secure, data-supported transfer from the R&D laboratory to process plants and significantly accelerate development and scale-up phases. Manufacturers benefit from stable, reproducible measurements that significantly increase quality, yield and process understanding. Thanks to short analysis times, critical reaction processes can be detected early and process times significantly reduced. The technology can be used flexibly in upstream and downstream processes and supports consistent process control. Raman thus forms a central basis for modern PAT and QbD strategies in biopharmaceutical production.

Raman spectroscopy from Endress+ Hauser enables precise inline and real-time measurements in all phases of biopharmaceutical processes. The Raman Rxn2 analyzer is designed for laboratory and pilot plants and supports sample determination, R&D projects and early process development. In addition, the Rxn-46 probe ensures seamless integration into Ambr®, BioPAT® Spectro and Biostat STR® single-use bioreactors. The optical Raman system for single-use bioreactors combines reusable, non-contact optics with a sterile disposable sleeve and delivers reliable spectra without the need for cleaning. Bio-Multi-Optics and Bio-Sleeves are available for benchtop systems, ensuring high sterility and stable signal quality. The Raman Flow Bench with Flow Cell enables precise monitoring of DSP even at low volume flows. The Raman data library offers real-time visualization, audit trails and a cGxP option.