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A sulfonamide (compound) is a compound that contains this group. The general formula is RSO2NH2, where R is some organic group. For example, "methanesulfonamide" is CH3SO2NH2. Any sulfonamide can be considered as derived from a sulfonic acid by replacing a hydroxyl group with an amine group.
In medicine, the term "sulfonamide" is sometimes used as a synonym for sulfa drug, a derivative or variation of sulfanilamide.
Sulfonamides can be prepared in the laboratory in many ways:
In this example the reactant is aniline and the catalysts are triethylamine and iodine. Sulfur dioxide is believed to be activated through a series of intermediates: Et3N-I+-I-, Et3N-I+-I3- and Et3N+-SO2-.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Sulfonamide_(chemistry)". A list of authors is available in Wikipedia.|