To use all functions of this page, please activate cookies in your browser.
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Abgenix Announces Initiation of Phase II Clinical Trial of ABX-EGF in Colorectal Cancer
31-12-2001: Abgenix, Inc. (Nasdaq:ABGX - news) announced today the initiation of a Phase II clinical trial of ABX-EGF in patients with colorectal cancer. ABX-EGF is a fully human monoclonal antibody against the epidermal growth factor receptor (EGFr), a receptor identified in many solid tumor types. This clinical trial, the third Phase II study of ABX-EGF, is designed to assess the safety and efficacy of ABX-EGF as monotherapy in patients with metastatic colorectal cancer who have previously failed chemotherapy. ABX-EGF is being developed in collaboration with Immunex Corporation.
This multi-center, open-label Phase II study will enroll up to 100 patients. Patients will receive intravenous infusions of 2.5 mg/kg of ABX-EGF weekly over an 8-week treatment cycle, for up to 6 cycles.
``We are pleased to advance our clinical oncology program with the start of this third Phase II trial for ABX-EGF,'' stated R. Scott Greer, chairman and chief executive officer of Abgenix. ``Our goal is to provide effective, antibody-based therapeutic options for cancer patients.''
Preliminary results of an ongoing Phase I clinical trial of ABX-EGF show that it is well tolerated and shows biological activity at low doses. Thus far, three patients in the Phase I study have achieved stable disease/minor response. Other Phase II studies of ABX-EGF in kidney cancer and non-small cell lung cancer are currently ongoing.
- 1Is it safe to pee in the pool?
- 2More dangerous chemicals in everyday life
- 3Caflon® surfactants from Univar as substitutes for banned nonylphenol ethoxylates
- 4New Fluka and Riedel-de Haën Catalog Features Over 1,500 New Products
- 5Human skin grown in lab can replace animal testing
- 6Drew Industrial Division of Ashland Specialty Chemical Company purchases industrial water-treatment business of London-based Fernox
- 7EquipNet expands business in Australia and South East Asia
- 8Tobacco as an alternative for producing bioethanol
- 9Knoll AG: Pharma business sold for $6.9 billion:
- 10Largest and most efficient BOPP line for Africa