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13 Current white paper about the topic mass spectrometry

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Chlorine Production - Eliminating Mercury

The role of trace element analysis in the membrane process

20-09-2013

Nearly all industrial chlorine production is by the electrolysis of brine using a membrane cell. The efficiency of the membrane process can be impaired by the presence of trace impurities in the brine. This can be done using Inductively Coupled Plasma–Optical Emission Spectroscopy (ICP-OES). This paper illustrates how the design and performance of the SPECTRO ARCOS ICP-OES make it the instrument of choice for this demanding application....

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Sample Preparation for MALDI Imaging with SunCollect System

02-11-2012

During the last years, matrix-assisted laser desorption/ionization mass spectrometry has been subject to considerable improvements. Whereas the focus of MALDI before has mostly been on the analysis of peptides and proteins, the development and progress of MALDI imaging have clearly expanded its options. The aim of MALDI imaging is to provide localized information on diverse analytes in various...

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GC-C-IRMS Determination of Hormones

eVol® Reduces Interference Caused by Solvents and Plastic Pipette Tips

26-09-2011

By amending methodology to utilize eVol® for sample preparation processes for GC-C-IRMS C isotope ratio analysis, the ISORA department has: improved sample preparation conditions and the GC-C-IRMS analysis results by removing the risk of ghost peaks, and increased their workflow, been able to work more rapidly while maintaining ergonomic practice for laboratory staff, increased liquid handling accuracy ...

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A granular look at sugar

Use of novel analysis methods

12-01-2011

Our experience with sugar starts in early childhood – since breast milk contains lactose. Human sensory perception alone is, however, not enough to properly assess the useful but also potentially harmful effects of an age-old sweetener (saccharose). Nutrition researchers and physicians have, for this reason, been focusing attention for some time on sugar compounds, particularly glucose...

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Characterizing Biotherapeutics with HPLC

Smart Solutions for large Molecules

24-11-2010

As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmaceutical to approval at the regulatory agencies. The introduction of the first so-called biosimilars in Europe further increased the demand for highly efficient analysis methods. The continuous development of new stationary phases for the common modes of biochromatography, such as size exclusion, ion exchange and hydrophilic interaction chromatography support biochemists in increasing lab productivity and establishing high-throughput HPLC analysis not only for small molecules but also for large biopolymers...

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Increased productivity for downstream processing of biotherapeutics

16-11-2010

Polymer-based chromatographic resins featuring high mechanical and chemical stability and high protein binding capacities can help to increase the throughput and robustness of biopharmaceutical manufacturing processes. Advances in genetic engineering and cell culture technology have raised upstream productivity in the production of recombinant proteins. Increased titres of up to 10 g/l stress the need for highly efficient and robust downstream processes (DSP). Most industrial bioprocess development groups apply generic DSP platforms that are designed to purify various candidates of the same class of proteins applying the same process design. Besides various filtration and virus inactivation steps, they usually involve two or three chromatographic unit operations with orthogonal separation modes. The use of high capacity chromatographic resins can help to overcome the DSP bottleneck by increasing process throughput and robustness...

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Field-Flow Fractionation - The Universal Separation Principle for Particle and Macromolecule Characterization

22-09-2010

High molecular weight polymers, bio molecules or particles in a range of a few nanometers up to several microns are more and more important in science and technology. Many applications are based on the specific properties of these materials. For this reason, an exact knowledge of the molar mass or particle sizes distribution is essential for later application as well as for optimization of the production processes or quality control. In addition the knowledge about the chain structure of macromolecules or biopolymers as well as about the shape of particles is often necessary. For this reason those samples, which often can be very complex systems, have to be separated according to parameters such as e.g. hydrodynamic volume or molecular weight. After the separation process the resulting narrow dispersed fractions are detected with different techniques....

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Size and element specific determination of Ag nanoparticles in consumer spray products using asymmetric flow field flow fractionation (AF4) coupled to ICPMS

10-09-2010

The use of nanoparticles in consumer products shows a tremendous increase over the past years. A study of the Woodrow Wilson International Centre for Scholars reported that between 2005 and today the number of products based on nanoparticles increased almost twentyfold from 54 to 1015. As active compounds these products contain ZnO for surface protection, TiO2 for sun screen or Ag for anti-bacterial purposes, only to name a few applications. Furthermore, Si, C and Au are frequently used. So far, no data are available concerning the release and the behaviour of nanoparticles during the spray process. Therefore, in spite of their beneficial properties, possible risks for humans and the environment need to be thoroughly investigated. Especially the exposure pathway via the lung seems to be very critical, as could be shown in a study recently published in the Journal of Nanoparticle Research...

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Absolute Molar Mass Characterisation

27-11-2009

Multi-angle light scattering coupled to SEC or other fractionation methods can provide an absolute means for measuring the molar mass, size and distribution of proteins, polymers and particles of all sorts. Wyatt Technology's MALS also enables the elucidation of additional data such as branching, conformation, and eluent behaviour. The same instrumentation also allows observation of molecular interactions in a real-time environment. As MALS is an absolute mass and size measuring technique it is insensitive to the separation mechanism and as such is ideal for both highly variable research applications as well as routine quality assurance of previously characterised samples...

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The Determination of Hazardous Substances According to RoHS and WEEE Directives

28-08-2005

1st July 2006 is an important deadline for the electro- and electronics industries. This date bans hazardous substances like lead, cadmium, mercury, hexavalent chromium and polybrominated biphenyls and diphenyl ethers from electro- and electronic equipment. This restriction, even though in discussion since 1991, has become more and more important from year to year because of tons of electronic waste releasing toxic substances which are accumulated in the environment, the food chain and all human beings. In order to enforce the substances ban and the limitation or substitution of hazardous components, elemental analysis is obviously the most important control measure for monitoring limiting values. This requires precise analytical systems such as X-ray fluorescence, ICP- and atomic absorption spectrometers. These instruments are able to detect trace concentrations of hazardous compounds - for example cadmium, using an atomic absorption spectrometer in the flame atomization mode up to 0.1 mg/L, or using the di...

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