To use all functions of this page, please activate cookies in your browser.
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as phorbol 12-myristate 13-acetate (PMA), is diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC results from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol. TPA is also being studied as a drug in the treatment of hematologic cancer. TPA is not to be confused with tPA, the former is a small molecule drug, whereas the latter is an enzyme. TPA was first found in the croton plant, a shrub found in Southeast Asia, exposure to which provokes a poison ivy-like rash. It is currently undergoing phase 1 clinical trials.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "12-O-Tetradecanoylphorbol-13-acetate". A list of authors is available in Wikipedia.|