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Tetradecanoylphorbol acetate
IUPAC name 12-O-tetradecanoylphorbol-13-acetate
Other names TPA, PMA, Phorbol myristate acetate,
Tetradecanoylphorbol acetate.
CAS number 16561-29-8
Molecular formula C36H56O8
Molar mass 616.83 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as phorbol 12-myristate 13-acetate (PMA), is diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC results from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol. TPA is also being studied as a drug in the treatment of hematologic cancer. TPA is not to be confused with tPA, the former is a small molecule drug, whereas the latter is an enzyme. TPA was first found in the croton plant, a shrub found in Southeast Asia, exposure to which provokes a poison ivy-like rash. It is currently undergoing phase 1 clinical trials.


    This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "12-O-Tetradecanoylphorbol-13-acetate". A list of authors is available in Wikipedia.
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