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ATP citrate lyase

ATP citrate lyase
Symbol ACLY
Entrez 47
HUGO 115
OMIM 108728
RefSeq NM_001096
UniProt P53396
Other data
EC number
Locus Chr. 17 q21.2

ATP citrate lyase is an enzyme that represents an important step in fatty acid biosynthesis.



In the presence of ATP and Coenzyme A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and orthophosphate:

citrate + ATP + CoA-->oxaloacetate + Acetyl-CoA + ADP + Pi.

This enzyme was formerly listed as EC[1]


The enzyme is cytosolic in plants[2] and animals.


The enzyme is composed of two subunits in green plants (including Chlorophyceae, Marchantimorpha, Bryopsida, Pinaceae, monocotyledons, and eudicots), species of fungi, Glaucophytes, Chlamydomonas, and prokaryotes.

Animal ACL enzymes are homomeric, presumably an evolutionary fusion of the ACLA and ACLB genes probably occurred early in the evolutionary history of this kingdom.[3]


  1. ^ MeSH ATP+Citrate+Lyase
  2. ^ Kaethner TM, ap Rees T. Planta. 1985;163:290;[1]
  3. ^

This article incorporates text from the National Library of Medicine, a public domain work of the United States Government.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ATP_citrate_lyase". A list of authors is available in Wikipedia.
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