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Systematic (IUPAC) name
9-(4-methoxy-2,3, 6-trimethyl-phenyl)- 3,7-dimethyl-nona-2,4,6,8- tetraenoic acid
CAS number 55079-83-9
ATC code D05BB02
PubChem 6437841
DrugBank APRD00778
Chemical data
Formula C21H26O3 
Mol. mass 326.429 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Acitretin (trade name Soriatane®) is a second generation retinoid. It is taken orally, and is typically used for psoriasis.

It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.

Women must avoid becoming pregnant for at least 3 years after discontinuing acitretin. In comparison, etretinate was not recommended at all for women who planned to become pregnant.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Acitretin". A list of authors is available in Wikipedia.
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