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Methoxsalen



Methoxsalen
Systematic (IUPAC) name
9-methoxy-7H-furo[3,2-g]chromen-7-one
Identifiers
CAS number 298-81-7
ATC code D05AD02 D05BA02
PubChem 4114
DrugBank APRD00157
Chemical data
Formula C12H8O4 
Mol. mass 216.19 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life ~2 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Methoxsalen (marketed under the trade name Oxsoralen) is a drug used to treat psoriasis in conjunction with exposing the skin to sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. The dosage comes in 10mg tablets, which are taken in the amount of 30mg 75 minutes before a PUVA light treatment.

Additional recommended knowledge

Risks and side effects

Patients with high blood pressure or a history of liver problems are at risk for inflammation and irreparable damage to both liver and skin. The eyes must be protected from UVA radiation. Side effects include nausea, headaches, dizziness, and in rare cases insomnia.

Cultural aspects

Author John Howard Griffin used the chemical to darken his skin in order to investigate racial segregation in the south. He wrote the non-fiction book Black Like Me about his experiences.[1]

References

  1. ^ Dead Like Me on snopes.com
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Methoxsalen". A list of authors is available in Wikipedia.
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