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Belatacept



Belatacept?
Therapeutic monoclonal antibody
Source recombinant
Target CTLA 4
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Belatacept is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4 [1], which is a molecule crucial for T-cell costimulation, selectively blocking the process of T-cell activation. It was developed by Bristol-Myers-Squibb. It differs from abatacept (Orencia) by only 2 amino acids.

Additional recommended knowledge

It is intended to provide extended graft survival while limiting the toxicity generated by standard immune suppressing regimens, such as calcineurin inhibitors.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Belatacept". A list of authors is available in Wikipedia.
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