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Systematic (IUPAC) name
CAS number 146-64-4
ATC code A03BB01
PubChem 160883
Chemical data
Formula C21H30NO4+
Mol. mass 360.467 g/mol
Pharmacokinetic data
Bioavailability <1%
Protein binding Low
Metabolism  ?
Half life 5 hours
Excretion Renal (50%) and fecal
Therapeutic considerations
Pregnancy cat.


Legal status

Pharmacy Only (S2)(AU) GSL(UK)

Routes Oral, rectal, intravenous

Butylscopolamine, also known as scopolamine butylbromide and hyoscine butylbromide is an anticholinergic agent[1] used as an abdominal-specific antispasmodic. It is marketed under the trade name Buscopan by Boehringer Ingelheim GmbH, Germany, who also offer a combination of butylscopolamine and acetaminophen, marketed under the name Buscopan Plus.

Butylscopolamine is used to treat pain and discomfort caused by abdominal cramps or other spasmodic activity in the digestive system. When taken orally, it cannot enter the bloodstream or otherwise leave the digestive tract, so that it is only able to affect the smooth muscles of the digestive system as it passes through. It is not an analgesic in the normal sense, since it doesn't 'mask' or 'cover over' the pain, but rather works to prevent painful cramps and spasms from occurring in the first place.


Butylscopolamine is often prescribed at a low dosage, commonly 10mg three times a day, as a means of managing some of the symptoms of Irritable bowel syndrome.


  1. ^ Effects of -Adrenergic Stimulation on the Acutely Obstructed Ureter in Dogs Makoto Murakami, Yoshitaka Tomiyama, Kohichi Hayakawa, Masuo Akahane, Yukiyoshi Ajisawa, Young-Chol Park, Norio Ohnishi, Takahide Sugiyama and Takashi Kurita. Division of Discovery Research, Kissei Pharmaceutical Co., Ltd., Nagano (M.M., Y.T., K.H., M.A., Y.A.); and Department of Urology, Kinki University School of Medicine, Osaka, Japan (Y.-C.P., N.O., T.S., T.K.)
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Butylscopolamine". A list of authors is available in Wikipedia.
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