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Casein kinase 2

The Casein kinase 2 (EC is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.

casein kinase 2, alpha 1 polypeptide
Symbol(s) CSNK2A1
Entrez 1457
OMIM 115440
casein kinase 2, alpha prime polypeptide
Symbol(s) CSNK2A2
Entrez 1459
OMIM 115442
casein kinase 2, beta polypeptide
Symbol(s) CSNK2B
Entrez 1460
OMIM 115441

Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation[1]. A Pertussis toxin-sensitive G protein and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.

Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm [2]

See also


  1. ^ Y. Gao and H. Y. Wang (2006) "Casein kinase 2 is activated and essential for wnt/beta-catenin signaling" in Journal of Biological Chemistry Entrez PubMed 16672224
  2. ^ X. Xu, P. Toselli, L. Russell and D. Seldin (1999) "Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit" in Nature Genetics Volume 23, pages 118-121. Entrez PubMed 10471512
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Casein_kinase_2". A list of authors is available in Wikipedia.
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