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Transcription Factor II D

Transcription Factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] TFIID is itself composed of several subunits called TBP-associated factors (TAFs, of which there are 14) and the TATA Binding Protein (TBP).

In a test tube, only TBP is necessary for transcription at promoters that contain a TATA box.[2] TAFs, however, add promoter selectivity, especially if there is no TATA box sequence for TBP to bind to.

Subunits in the TFIID complex include:[2]

  • TBP
  • TAFII250
  • CIF150
  • TAFII130/135
  • TAFII100
  • TAFII70/80
  • TAFII31/32
  • TAFII20
  • TAFII15
  • TAFII28
  • TAFII68
  • TAFII55
  • TAFII30
  • TAFII18
  • TAFII105

See also


  1. ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall, p636-637. ISBN 0-13-144946-X. 
  2. ^ a b Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Transcription_Factor_II_D". A list of authors is available in Wikipedia.
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