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Transcription Factor II B

General transcription factor IIB
PDB rendering based on 1c9b.
Available structures: 1c9b, 1dl6, 1rly, 1ro4, 1tfb, 1vol, 2phg
Symbol(s) GTF2B; TF2B; TFIIB
External IDs OMIM: 189963 MGI: 2385191 Homologene: 1158
RNA expression pattern

More reference expression data

Human Mouse
Entrez 2959 229906
Ensembl ENSG00000137947 ENSMUSG00000028271
Uniprot Q00403 Q3ULN2
Refseq NM_001514 (mRNA)
NP_001505 (protein)
NM_145546 (mRNA)
NP_663521 (protein)
Location Chr 1: 89.09 - 89.13 Mb Chr 3: 142.7 - 142.72 Mb
Pubmed search [1] [2]

Transcription Factor II B (TFIIB) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] It is encoded by the TFIIB gene.[2][3]

Transcription factor IIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. The protein serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.[4] It is involved in the selection of the transcription start site: mutations in TFIIB cause a shift in the transcription start site.[5]

See also


  1. ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall, p636-637. ISBN 0-13-144946-X. 
  2. ^ Ha I, Lane WS, Reinberg D (1991). "Cloning of a human gene encoding the general transcription initiation factor IIB". Nature 352 (6337): 689-95. doi:10.1038/352689a0. PMID 1876184.
  3. ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61-4. doi:10.1093/hmg/3.1.61. PMID 8162052.
  4. ^ Entrez Gene: GTF2B general transcription factor IIB.
  5. ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.

Further reading

  • Roeder RG (1996). "The role of general initiation factors in transcription by RNA polymerase II.". Trends Biochem. Sci. 21 (9): 327-35. PMID 8870495.
  • Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193-205. doi:10.1089/104454904773819789. PMID 15142377.
  • Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153-67. doi:10.1196/annals.1321.013. PMID 15265780.
  • Seelamgari A, Maddukuri A, Berro R, et al. (2006). "Role of viral regulatory and accessory proteins in HIV-1 replication.". Front. Biosci. 9: 2388-413. PMID 15353294.
  • Ing NH, Beekman JM, Tsai SY, et al. (1992). "Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).". J. Biol. Chem. 267 (25): 17617-23. PMID 1517211.
  • Malik S, Hisatake K, Sumimoto H, et al. (1991). "Sequence of general transcription factor TFIIB and relationships to other initiation factors.". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9553-7. PMID 1946368.
  • Klemm RD, Goodrich JA, Zhou S, Tjian R (1995). "Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation.". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5788-92. PMID 7597030.
  • Veschambre P, Simard P, Jalinot P (1995). "Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo.". J. Mol. Biol. 250 (2): 169-80. doi:10.1006/jmbi.1995.0368. PMID 7608968.
  • Desai-Yajnik V, Hadzic E, Modlinger P, et al. (1995). "Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator.". J. Virol. 69 (8): 5103-12. PMID 7609079.
  • Cavaillès V, Dauvois S, L'Horset F, et al. (1995). "Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.". EMBO J. 14 (15): 3741-51. PMID 7641693.
  • Nakshatri H, Nakshatri P, Currie RA (1995). "Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter.". J. Biol. Chem. 270 (33): 19613-23. PMID 7642649.
  • Abendroth FD, Peterson SR, Galman M, et al. (1995). "Identification of human autoantibodies to transcription factor IIB.". Nucleic Acids Res. 23 (14): 2770-4. PMID 7651839.
  • Bagby S, Kim S, Maldonado E, et al. (1995). "Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein.". Cell 82 (5): 857-67. PMID 7671313.
  • Nikolov DB, Chen H, Halay ED, et al. (1995). "Crystal structure of a TFIIB-TBP-TATA-element ternary complex.". Nature 377 (6545): 119-28. doi:10.1038/377119a0. PMID 7675079.
  • Schmitz ML, Stelzer G, Altmann H, et al. (1995). "Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators.". J. Biol. Chem. 270 (13): 7219-26. PMID 7706261.
  • Yu L, Zhang Z, Loewenstein PM, et al. (1995). "Molecular cloning and characterization of a cellular protein that interacts with the human immunodeficiency virus type 1 Tat transactivator and encodes a strong transcriptional activation domain.". J. Virol. 69 (5): 3007-16. PMID 7707527.
  • Yu L, Loewenstein PM, Zhang Z, Green M (1995). "In vitro interaction of the human immunodeficiency virus type 1 Tat transactivator and the general transcription factor TFIIB with the cellular protein TAP.". J. Virol. 69 (5): 3017-23. PMID 7707528.
  • Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263-72. PMID 7757816.
  • Franklin CC, McCulloch AV, Kraft AS (1995). "In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.". Biochem. J. 305 ( Pt 3): 967-74. PMID 7848298.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Transcription_Factor_II_B". A list of authors is available in Wikipedia.
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