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V-fos FBJ murine osteosarcoma viral oncogene homolog
PDB rendering based on 1a02.
Available structures: 1a02, 1fos, 1s9k
Symbol(s) FOS; c-fos
External IDs OMIM: 164810 MGI: 95574 Homologene: 3844
RNA expression pattern

More reference expression data

Human Mouse
Entrez 2353 14281
Ensembl ENSG00000170345 ENSMUSG00000021250
Uniprot P01100 Q3U463
Refseq NM_005252 (mRNA)
NP_005243 (protein)
NM_010234 (mRNA)
NP_034364 (protein)
Location Chr 14: 74.82 - 74.82 Mb Chr 12: 86.36 - 86.37 Mb
Pubmed search [1] [2]

In molecular biology, c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at the C-terminus. Transcription of c-Fos is upregulated in response to many extracellular signals, e.g. growth factors. Additionally, phosphorylation by MAPK, PKA, PKC or cdc2 alters the activity and stability of c-Fos. Members of the Fos family dimerise with Jun to form the AP-1 transcription factor, which upregulates transcription of a diverse range of genes involved in everything from proliferation and differentiation to defense against invasion and cell damage.

The AP-1 complex has been implemented in transformation and progression of cancer, and both Fos and Jun were first discovered in rat fibroblasts.

The viral homologue of c-Fos, v-Fos, is found in the retrovirus Finkel–Biskis–Jinkins murine osteogenic sarcoma virus.

See also

Further reading

  • Murphy LC, Alkhalaf M, Dotzlaw H, et al. (1994). "Regulation of gene expression in T-47D human breast cancer cells by progestins and antiprogestins.". Hum. Reprod. 9 Suppl 1: 174-80. PMID 7962462.
  • Pompeiano M, Cirelli C, Arrighi P, Tononi G (1997). "c-Fos expression during wakefulness and sleep.". Neurophysiologie clinique = Clinical neurophysiology 25 (6): 329-41. doi:10.1016/0987-7053(96)84906-9. PMID 8904195.
  • Herrera DG, Robertson HA (1997). "Activation of c-fos in the brain.". Prog. Neurobiol. 50 (2-3): 83-107. PMID 8971979.
  • Velazquez Torres A, Gariglio Vidal P (2002). "[Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus]". Rev. Invest. Clin. 54 (3): 231-42. PMID 12183893.


  1. Karin Milde-Langosch, 2005. The Fos family of transcription factors and their role in tumourigenesis. European Journal of Cancer 41(16):2449-2461. Abstract + Full Text

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "C-Fos". A list of authors is available in Wikipedia.
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