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Transcription Factor II E

general transcription factor IIE, polypeptide 1, alpha 56kDa
Symbol GTF2E1
Alt. Symbols TF2E1
Entrez 2960
HUGO 4650
OMIM 189962
RefSeq NM_005513
UniProt P29083
Other data
Locus Chr. 3 q21-q24
general transcription factor IIE, polypeptide 2, beta 34kDa
Symbol GTF2E2
Alt. Symbols TF2E2
Entrez 2961
HUGO 4651
OMIM 189964
RefSeq NM_002095
UniProt P29084
Other data
Locus Chr. 8 p12

Transcription Factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1]

Transcription Factor II E is encoded by the GTF2E1 and GTF2E2 genes.[2][3][4] TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.[5]

See also


  1. ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall, p636-637. ISBN 0-13-144946-X. 
  2. ^ Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M (1992). "Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences". Nucleic Acids Res. 20 (21): 5838. PMID 1454543.
  3. ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61-4. PMID 8162052.
  4. ^ Sumimoto H, Ohkuma Y, Sinn E, Kato H, Shimasaki S, Horikoshi M, Roeder RG (1991). "Conserved sequence motifs in the small subunit of human general transcription factor TFIIE". Nature 354 (6352): 401-4. doi:10.1038/354401a0. PMID 1956404.
  5. ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Transcription_Factor_II_E". A list of authors is available in Wikipedia.
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