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HMGA



high mobility group AT-hook 1
Identifiers
Symbol HMGA1
Alt. Symbols HMGIY
Entrez 3159
HUGO 5010
OMIM 600701
RefSeq NM_145901
UniProt P17096
Other data
Locus Chr. 6 p21
high mobility group AT-hook 2
Identifiers
Symbol HMGA2
Alt. Symbols HMGIC
Entrez 8091
HUGO 5009
OMIM 600698
RefSeq NM_003484
UniProt P52926
Other data
Locus Chr. 12 q15

HMGA is a family of high mobility group proteins characterized by an AT-hook. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture".[1] A recent study has shown variations in HMGA2 to have a moderate association with adult height.[2][3]

Additional recommended knowledge

See also

  • HMGA1
  • HMGA2

References

  1. ^ Mayr C, Hemann MT, Bartel DP (2007). "Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation". Science 315 (5818): 1576–9. doi:10.1126/science.1137999. PMID 17322030.
  2. ^ BBC NEWS. Retrieved on 2007-09-03.
  3. ^ Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM (2007). "A common variant of HMGA2 is associated with adult and childhood height in the general population". Nat. Genet. 39 (10): 1245–50. doi:10.1038/ng2121. PMID 17767157.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "HMGA". A list of authors is available in Wikipedia.
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