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Daidzein



Daidzein
IUPAC name 7-Hydroxy-3-(4-hydroxyphenyl)chromen-4-one
Other names 4',7-Dihydroxyisoflavone
Daidzeol
Isoaurostatin
Identifiers
CAS number 486-66-8
PubChem 5281708
SMILES C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O
Properties
Molecular formula C15H10O4
Molar mass 254.237 g/mol
Appearance Pale yellow prisms
Melting point

315-323 °C (decomposes)

Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Daidzein is one of several known isoflavones. Isoflavones compounds, such as daidzein and genistein, are found in a number of plants, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Soy isoflavones are a group of compounds found in and isolated from the soybean. Besides functioning as antioxidants, many isoflavones have been shown to interact with animal and human estrogen receptors, and are therefore known as phytoestrogens. Soy isoflavones also produce non-hormonal effects.

Additional recommended knowledge

Isoflavones act as antioxidants to counteract damaging effects of free radicals in tissues. Isoflavones can act like estrogen in stimulating development and maintenance of female characteristics or they can block cells from using other forms of estrogen[citation needed]. Isoflavones also have been found to have antiangiogenic effects (blocking formation of new blood vessels)[citation needed], and may block the uncontrolled cell growth associated with cancer, most likely by inhibiting the activity of substances in the body that regulate cell division and cell survival (growth factors)[citation needed].

Studies show that groups of people who eat large amounts of soy-based products have lower incidences of breast, colon, endometrial, and prostate cancers than the general (US) population[citation needed]. Initial studies of soy isoflavone mixtures containing genistein, daidzein, and glycitein have found them safe for human use[2]. Laboratory studies using animals models have shown that both soy and isoflavones can be protective against cancer when given during early life but can stimulate response to cancer-causing chemicals when given during fetal development or when circulating levels of estrogen are low (menopause)[citation needed].

References

  1. ^ Merck Index, 11th Edition, 2805.
  2. ^ Safety of soy-based infant formulas containing isoflavones PMID 15113975
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Daidzein". A list of authors is available in Wikipedia.
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