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Dimethyl pimelimidate dihydrochloride

Dimethyl pimelimidate dihydrochloride
IUPAC name 1,7-dimethoxyheptane-1,7-diimine dihydrochloride
Other names Pimelimidic acid dimethyl ester dihydrochloride,
dimethyl heptane-1,7-diimidate dihydrochloride
CAS number 58537-94-3
PubChem 11402688
Molecular formula [CH3OC(=NH)CH2CH2]2CH2 · 2HCl
Molar mass 259.17 g/mol
Appearance white crystalline powder
Melting point

122 °C

Solubility in water Slightly soluble
NFPA 704
Flash point Not determined
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Dimethyl pimelimidate dihydrochloride (IUPAC systematic name: 1,7-dimethoxyheptane-1,7-diimine dihydrochloride) (often abbreviated as DMP), is an organic chemical compound with two functional imine groups, which both bind to free amino groups at pH range 7.0-10.0 to form amidine bonds.


DMP is used mainly as bifunctional coupling reagent to link proteins. It is often used to prepare antibody affinity columns. The appropriate antibody is first incubated with Protein A or Protein G-agarose and allowed to bind. DMP is then added to couple the molecules together.

Health effects

Dimethyl pimelimidate (DMP) is irritating to the eyes, skin, mucous membranes and upper respiratory tract. It can exert harmful effects by inhalation, ingestion, or skin absorption.


  • MSDS safety data, also available in other languages
  • Sigma-Aldrich product detail
  • MSDS datasheet
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dimethyl_pimelimidate_dihydrochloride". A list of authors is available in Wikipedia.
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