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Eprosartan



Eprosartan
Systematic (IUPAC) name
4-[[2-butyl-5-(2-carboxy-3-thiophen-2-yl-prop-1-enyl)-

imidazol-1-yl]methyl]benzoic acid

Identifiers
CAS number 133040-01-4
ATC code C09CA02  ?
PubChem 9670
DrugBank APRD00950
Chemical data
Formula C23H24N2O4S 
Mol. mass Eprosartan mesylate: 520.625 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 5 to 9 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status

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Routes Oral

Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. It is marketed as Teveten® by the Biovail Corporation in the United States and by Solvay Pharmaceuticals elsewhere. It is sometimes paired with hydrochlorothiazide.

Additional recommended knowledge

The drug acts on the renin-angiotensin system in two ways to decrease total peripheral resistance. First, it blocks the binding of angiotensin II to AT1 receptors in vascular smooth muscle, causing vascular dilatation. Second, it inhibits sympathetic norepinephrine production, further reducing blood pressure.

As with other angiotensin II receptor antagonists, eprosartan is generally better tolerated than enalapril (an ACE inhibitor), especially among the elderly.[1]

References

  1. ^ Ruilope L, Jäger B, Prichard B (2001). "Eprosartan versus enalapril in elderly patients with hypertension: a double-blind, randomized trial". Blood Press. 10 (4): 223-9. PMID 11800061.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Eprosartan". A list of authors is available in Wikipedia.
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