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Systematic (IUPAC) name
3-carboxylic acid
CAS number 85441-61-8
ATC code C09AA06
PubChem 54892
DrugBank APRD00523
Chemical data
Formula C25H30N2O5 
Mol. mass 438.516 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 97%
Metabolism  ?
Half life 2 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status

Prescription only

Routes  ?

Quinapril (marketed under the brand name Accupril by Pfizer) is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure.



Quinapril is a prodrug. It is converted to its active metabolite, quinaprilat, in the liver.

Mechanism of action

Main article: ACE inhibitor
See also: Angiotensin and renin-angiotensin system

Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood.


Quinapril is indicated for the treatment of high blood pressure (hypertension) and as adjunctive therapy in the management of heart failure. It may be used for the treatment of hypertension by itself or in combination with thiazide diuretics, and with diuretics and digoxin for heart failure.


  • Pregnancy
  • Impaired renal and liver function
  • Patients with a history of angioedema related to previous treatment with an ACE inhibitor.
  • Hypersensitive to Quinapril

    Side effects

    Side effects of quinapril include dizziness, cough, vomiting, upset stomach and fatigue.

    This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Quinapril". A list of authors is available in Wikipedia.
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