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Telmisartan



Telmisartan
Systematic (IUPAC) name
2-[4-[[4-methyl-6-(1-methylbenzoimidazol-2-yl)-
2-propyl-benzoimidazol-1-yl]methyl]phenyl]
benzoic acid
Identifiers
CAS number 144701-48-4
ATC code C09CA07
PubChem 65999
DrugBank APRD01247
Chemical data
Formula C33H30N4O2 
Mol. mass 514.617 g/mol
Pharmacokinetic data
Bioavailability 42–100%
Protein binding ≥99.5%
Metabolism Minimal hepatic
Half life 24 hours
Excretion Faecal 97%
Therapeutic considerations
Pregnancy cat.

D (Au), D (U.S.)

Legal status

S4 (Au), POM (UK), ℞-only (U.S.)

Routes Oral

Telmisartan (INN) (pronounced /tɛlmɪˈsɑrtən/) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. It is marketed under the trade names Micardis (Boehringer Ingelheim) and Pritor or Kinzal (Bayer Schering Pharma).

Additional recommended knowledge

Pharmacology

Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.

New studies suggest that telmisartan may also have PPARγ agonistic properties that could potentially confer beneficial metabolic effects. This observation is currently being explored in clinical trials. In India it is available in the name of Telma by Glenmark Pharma according to www.sureshjain.com.

Clinical use

In India RANBAXY also markets it under the name of 'Teleact 20 mg"

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Telmisartan". A list of authors is available in Wikipedia.
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