To use all functions of this page, please activate cookies in your browser.
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
The Feist-Benary synthesis is an organic reaction between α-halogen ketones and β-dicarbonyl compounds to substituted furan compounds . This condensation reaction is catalyzed by amines such as ammonia and pyridine. The first step in the ring synthesis is related to the Knoevenagel condensation. In the second step the enolate displaces an alkyl halogen in a nucleophilic aliphatic substitution.
Additional recommended knowledge
A recent modification is the enantioselective interrupted Feist-Benary reaction chiral auxiliary based on the cinchona alkaloid quinine based in the presence of proton sponge to the hydroxydihydrofuran. This type of alkaloids is also used in asymmetric synthesis in the AD-mix. The alkaloid is protonated throughout the reaction and transfers its chirality by interaction of the acidic ammonium hydrogen with the dicarbonyl group of ethyl bromopyruvate in a 5-membered transition state.with a
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Feist-Benary_synthesis". A list of authors is available in Wikipedia.|