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Forskolin is a labdane diterpene that is produced by the Indian Coleus plant (Plectranthus barbatus). Forskolin is commonly used to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cyclic Adenosine Monophosphate (cyclic AMP or cAMP). Cyclic AMP is an important signal carrier that is necessary for the proper biological response of cells to hormones and other extracellular signals. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones. It acts by activating protein kinase A. Further reading: function of protein kinase A
Additional recommended knowledge
Potential medical use
Forskolin can also be used to promote nerve repair by increasing cAMP concetrations. Forskolin can activate or upregulate the proliferation of Schwann cells in culture, together with Fibroblast growth factor or Transforming Growth Factor-Beta.
Various experimental studies are underway in using Forskolin as an adjunct treatment for diseases such as Parkinsons and/or nerve damage caused by trauma/accident.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Forskolin". A list of authors is available in Wikipedia.|