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HLA-DR12


major histocompatibility complex, class II, DR12
Haplotypes groups	DQA01:DRB11201 to DQA01:DRB11203 DQA01:DRB11206
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 1201 to 1203 *1206
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*1201
EBI-HLA	DRB1*1202
EBI-HLA	DRB1*1203
EBI-HLA	DRB1*1306
Shared data
Locus	chr.6 6p21.31

HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.

Additional recommended knowledge

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Correct Test Weight Handling Guide: 12 Practical Tips

1 Serology
2 Alleles
3 Disease associations
4 Extended linkage
5 Genetic Linkage
6 References

Serology

DR12, DR5 and DR11 serotype recognition of the gene products of some DRB1*12 alleles^[1]
DRB1*	DR12	DR5	DR11	Sample
allele	%	%	%	size (N)
1201	83	4	2	893 ^[2]
1202	89			162
1203	>50			3
1206	>50			2

The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215

Alleles

There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common on the West Pacific Rim and particularly Indochina and the South Pacific.

Disease associations

DR12 is associated with vulval lichen sclerosus, ^[3] and undifferentiated spondyloarthritis.^[4]

DRB1*1201 is associated with iritis in juvenile arthritis^[5],primary antiphospholipid syndrome^[6], tiopronin intolerance in rheumatoid arthritis,^[7] adult chronic articular Still's disease^[8]

DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population,^[9] and narcolepsy in the Japanese population.

Extended linkage

DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease^[10]

DRB1*1201:DRB3*01/03: colorectal cancer^[11]

Genetic Linkage

Serotypes	DRA	DRB1	DRB3
DR12 Haplotypes
DR11(5)-DR52	*0101	*1201	*0101
	*0101	*1202	*0201
	*0101	*1202	*0202
	*0101	*1202	*0301
Serotypes	DRB1	DQA1	DQB1
DR12(5)-DQ7 (7.5, 3)	*1201	*0505	*0301
DR12(5)-DQ7 (7.5, 3)	*1202	*0505	*0301
DR12(5)-DQ7 (7.3, 3)	*1201	*0303	*0301
DR12(5)-DQ7 (7.4, 3)	*1201	*0401	*0301
DR12(5)-DQ7 (7.6, 3)	*1201	*0601	*0301
Serotypes	HLA-A	HLA-C	HLA-B	DRB1
A31(19)-Cw10-B51(5)-DR12(5)	*3101	*0304	*5101	*1202
A11-Cw9-B75(15)-DR12(5)	*1101	*0303	*1502	*1202
A2-Cw10-B13-DR12(5)	*0201	*0304	*1301	*1202

HLA-DR12 is genetically linked to DR52^[12] and HLA-DQ7 serotypes.

References

^ derived from IMGT/HLA
^ DR8 - 2%
^ Gao X, Barnardo M, Winsey S, Ahmad T, Cook J, Agudelo J, Zhai N, Powell J, Fuggle S, Wojnarowska F (2005). "The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus.". J Invest Dermatol 125 (5): 895-9. PMID 16297186.
^ Liao HT, Lin KC, Chen CH, et al (2007). "Human Leukocyte Antigens in Undifferentiated Spondyloarthritis". doi:10.1016/j.semarthrit.2007.04.004. PMID 17604825.
^ Cerna M, Vavrincova P, Havelka S, Ivaskova E, Stastny P (1994). "Class II alleles in juvenile arthritis in Czech children.". J Rheumatol 21 (1): 159-64. PMID 8151573.
^ Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients.". Arthritis Rheum 38 (9): 1340-1. PMID 7575732.
^ Ju LY, Paolozzi L, Delecoeuillerie G, et al (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis". Clin. Exp. Rheumatol. 12 (3): 249-54. PMID 7915222.
^ Fujii T, Nojima T, Yasuoka H, Satoh S, Nakamura K, Kuwana M, Suwa A, Hirakata M, Mimori T (2001). "Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease.". Rheumatology (Oxford) 40 (12): 1398-404. PMID 11752512.
^ Himmunngan P, Sangwatanaroj S, Petmitr S, Viroonudomphol D, Siriyong P, Patmasiriwat P (2006). "HLa-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)". Southeast Asian J. Trop. Med. Public Health 37 (2): 357-65. PMID 17124999.
^ Tighe M, Hall M, Barbado M, Cardi E, Welsh K, Ciclitira P (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population.". Tissue Antigens 40 (2): 90-7. PMID 1357780.
^ Bidwell J, Soong T, Raymond P, Doherty D, Hui K (1992). "HLA genotyping of colorectal carcinoma in the Chinese population.". Hum Immunol 34 (1): 19-23. PMID 1356954.
^ Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol. 65 (3): 270-6. doi:10.1016/j.humimm.2003.12.005. PMID 15041167.

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Category: HLA-DR haplotypes

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