My watch list  


Systematic (IUPAC) name
CAS number 77642-19-4
ATC code  ?
PubChem 5384563
Chemical data
Formula C29H35NO5 
Mol. mass 477.592 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Hitachimycin, also known as stubomycin, is a cyclic polypeptide produced by Streptomyces that acts as an antibiotic. It exhibits cytotoxic activity against mammalian cells, Gram-positive bacteria, yeast, and fungi, as well as hemolytic activity; this is mediated by changes at the cell membrane and subsequent lysis.[1] Owing to its cytotoxic activity against mammalian cells and tumors, it was first proposed as a antitumor antibiotic.[2]

As of 2007, it has not been used in a clinical setting.


  1. ^ Komiyama K, Edanami K, Tanoh A, Yamamoto H, Umezawa I (1983). "Studies on the biological activity of stubomycin". J. Antibiot. 36 (3): 301-11. PMID 6833150.
  2. ^ Umezawa I, Takeshima H, Komiyama K, Koh Y, Yamamoto H, Kawaguchi M (1981). "A new antitumor antibiotic, stubomycin". J. Antibiot. 34 (3): 259-65. PMID 7275806.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Hitachimycin". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE