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L-Iduronic acid (IdoA) is the major uronic acid component of the glycosaminoglycans (GAGs) dermatan sulfate and heparin. It is also present in heparan sulfate although here in a minor amount relative to its carbon-5 epimer glucuronic acid.
Additional recommended knowledge
IdoA is a hexapyranose sugar. Most hexapyranoses are stable in one of two chair conformations 1C4 or 4C1. L-iduronate is different and adopts more than one solution conformation, with an equilibrium existing between three low energy conformers. These are the 1C4 and 4C1 chair forms and an additional 2S0 skew-boat conformation.
IdoA may be modified by the addition of a O-sulfate group at carbon position 2 to form 2-O-sulfo-L-iduronic acid (IdoA2S).
When internally positioned within an oligosaccharide the 1C4 and 2S0 conformations (shown below for IdoA2S) predominate.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Iduronic_acid". A list of authors is available in Wikipedia.|