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Ifenprodil



Ifenprodil
IUPAC name 4-[2-[4-(cyclohexylmethyl)- 1-piperidinyl]-1-hydroxypropyl]phenol
Identifiers
CAS number 245-491-4
PubChem 3689
SMILES CC(C(C1=CC=C(C=C1)O)O) N2CCC(CC2)CC3=CC=CC=C3
Properties
Molecular formula C21H27NO2
Molar mass 325.445
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Ifenprodil is a selective inhibitor of the NMDA receptor.[1]

Additional recommended knowledge

References

  1. ^ Reynolds IJ, Miller RJ (1989). "Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines". Mol. Pharmacol. 36 (5): 758-65. PMID 2555674.

NMDA receptors are multimeric ionotropic glutamate receptors composed of likely four subunits. NR1 is obligate for functional expression. Other subunits include NR2A, NR2B, and the more recently discovered NR3 subunits. Ifenprodil selectively blocks NMDA receptors containing the NR2B subunit.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ifenprodil". A list of authors is available in Wikipedia.
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