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Mast cell stabilizer



Mast cell stabilizers are cromone medications used to prevent or control certain allergic disorders. They block a calcium channel essential for mast cell degranulation, stabilizing the cell and so prevent the release of histamine[1] and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate.

Additional recommended knowledge

As inhalers they are used to treat asthma, as nasal sprays to treat hay fever (allergic rhinitis) and as eye drops for allergic conjunctivitis. Finally in oral form they are used to treat the rare condition of mastocytosis.

References

  1. ^ http://www.mayoclinic.com/health/allergy-medications/AA00037
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mast_cell_stabilizer". A list of authors is available in Wikipedia.
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