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Beclometasone dipropionate

Beclometasone dipropionate
Systematic (IUPAC) name
2-oxo-ethyl] propanoate
CAS number 4419-39-0
ATC code A07EA07 D07AC15R01AD01R03BA01
PubChem 21700
DrugBank APRD00564
Chemical data
Formula C28H37ClO7 
Mol. mass 521.042 g/mol
Pharmacokinetic data
Bioavailability Converted to beclometasone-17-monopropionate (17-BMP) during absorption
Protein binding 87% of 17-BMP to albumin and transcortin
Metabolism By esterase enzymes found in most tissues
Half life 2.8 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status

Pharmacy Only (S2)(AU) POM(UK)

Routes Oral & nasal inhalation, topical

Beclometasone dipropionate (INN modified) or beclomethasone dipropionate (USAN, former BAN), also referred to as beclometasone (INN), is a potent Class A glucocorticoid steroid drug. In the form of an inhaler (e.g. Becotide), a wide number of brands of which are available, it is used for the prophylaxis of asthma. As a nasal spray (e.g. Beconase, Vancenase), it is used for the treatment of rhinitis (e.g. hayfever) and sinusitis. In some instances it is used by oral pathologists in the treatment of unusually severe canker sores.

As a cream or ointment (trade name Propaderm) it is used to treat severe inflammatory skin disorders (e.g. eczema) unresponsive to less potent steroids, but is generally avoided in the treatment of psoriasis due to the risk of rebound on withdrawal.


It is a white to creamy-white, odorless powder which is very slightly soluble in water, very soluble in chloroform, and freely soluble in acetone and in ethanol.

Side effects

Occasionally it may cause a cough upon inhalation. Deposition on the tongue and throat may promote oral candidiasis which appears as a white coating, possibly with irritation.[1][2][3] This may usually be prevented by rinsing the mouth with water after using the inhaler. Other side effects may rarely include unpleasant taste, hoarseness or nasal congestion, pain or headache and visual changes. Allergic reactions rarely may occur.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Beclometasone_dipropionate". A list of authors is available in Wikipedia.
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