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Systematic (IUPAC) name
5 - [(2Z) - 2 - (3 - carboxy - 4 - oxo - 1 - cyclohexa - 2,5 - dienylidene)hydrazinyl] - 2 - hydroxy - benzoic acid
CAS number 15722-48-2
ATC code A07EC03
PubChem 6003770
Chemical data
Formula C14H10N2O6 
Mol. mass 302.239g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 99%
Metabolism  ?
Half life 0.9 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status


Routes  ?

Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis. It is sold under the name Dipentum.

The chemical name is 3,3' -azobis (6-hydroxybenzoate)salicylic acid. It is sold as the disodium salt.

Like Balsalazide, Olsalazine is believed to deliver Mesalazine, or 5-aminosalicylic acid (5-ASA), past the small intestine, directly to the large intestine, which is that active site of disease in ulcerative colitis.


Olsalazine gained Food and Drug Administration (FDA) approval in 1990.


The drug is supplied by UCB Pharma.

Other indications

The Australian biotech company Giaconda has developed a combination therapy for treat constipation-predominant Irritable Bowel Syndrome that uses olsalazine and the anti-gout drug colchicine.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Olsalazine". A list of authors is available in Wikipedia.
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