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Systematic (IUPAC) name
CAS number 38212-30-5
ATC code  ?
PubChem 269722
Chemical data
Formula C11H16N2O 
Mol. mass 192.258 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism hepatic
Half life  ?
Excretion renal
Therapeutic considerations
Pregnancy cat.


Legal status
Routes oral

4-methoxyphenylpiperazine (Paraperazine, MeOPP, 4-MeOPP) is a piperazine derivative with stimulant effects which has been sold as an ingredient in "Party pills", initially in New Zealand and subsequently in other countries around the world.

MeOPP has been found in vitro to inhibit monoamine re-uptake and stimulate their release. This is a mechanism of action shared with drugs of abuse such as amphetamines, and MeOPP produces somewhat similar effects although it is much less potent and is thought to have relatively insignificant abuse potential. [1] Piperazine derivatives such as TFMPP have also been shown to exert a major part of their mechanism of action as non-selective serotonin agonists, and MeOPP has also been demonstrated to act in this way. [2] MeOPP is anecdotally said to induce significantly less anxiety than similar piperazines, and is usually taken at doses between 120 - 200mg. It does not produce prominent stimulant effects, but is instead said to be relaxing[citation needed], however it is often mixed with stimulant piperazine derivatives such as BZP for a combined effect.

See also

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "MeOPP". A list of authors is available in Wikipedia.
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