Mechanically-interlocked molecular architectures

Mechanically-interlocked molecular architectures are connections of molecules not through traditional bonds, but instead as a consequence of their topology. This connection of molecules is analogous to keys on a key chain loop. The keys are not directly connected to the key chain loop but they cannot be separated without breaking the loop. On the molecular level the interlocked molecules cannot be separated without significant distortion of the covalent bonds that make up the conjoined molecules. Examples of mechanically-interlocked molecular architectures include catenanes, rotaxanes, molecular knots, and molecular Borromean rings.

**Examples of mechanically-interlocked molecular architectures**
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The synthesis of such entangled architectures has been made efficient through the combination of supramolecular chemistry with traditional covalent synthesis, however mechanically-interlocked molecular architectures have properties that differ from both “supramolecular assemblies” and “covalently-bonded molecules”. Recently the terminology "mechanical bond" has been coined to describe the connection between the components of mechanically-interlocked molecular architectures. Although research into mechanically-interlocked molecular architectures is primarily focused on artificial compounds many examples have been found in biological systems including: cystine knots, cyclotides or lasso-peptides such as microcin J25 are protein, and a variety of peptides. There is a great deal of interest in mechanically-interlocked molecular architectures to develop molecular machines by manipulating the relative position of the components.