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Methoxyflurane



Methoxyflurane
Systematic (IUPAC) name
2,2-dichloro-1,1-difluoro-1-methoxy-ethane
Identifiers
CAS number 76-38-0
ATC code N01AB03
PubChem 4116
DrugBank APRD00744
Chemical data
Formula C3H4Cl2F2O 
Mol. mass 164.965 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes Inhalation

Methoxyflurane (C3H4Cl2F2O) is an inhalational anaesthetic used in the 1960s, but withdrawn because of detrimental effects on the kidneys. This was due to fluoride ions being produced by its metabolism in the kidney. Its minimum alveolar concentration (MAC) is 0.2, hence it is extremely potent. It has a high lipid solubility (oil:gas coefficient around 950) giving it a very slow onset/offset, thus undesirable for anesthetic purposes.

Additional recommended knowledge

Methoxyflurane is used extensively in Australian ambulance services, and in St John Ambulance as an emergency analgesic.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Methoxyflurane". A list of authors is available in Wikipedia.
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