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Additional recommended knowledge
Even though Cremophor EL has been shown to cause anaphylactic reactions in humans in several cases (both when given intraveneosly and orally), it is still debated whether or not propanidid itself may have contributed to the reactions.
It has been argued that the toxic effects or reactions to Propanidid (and Althesin) were due to the drugs themselves . Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer. This suggest that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Propanidid". A list of authors is available in Wikipedia.|