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Mutagen X



Mutagen X
Chemical name 3-Chloro-4-(dichloromethyl)-5-
hydroxy-5H-furan-2-one
Other names Mutagen X
MX
Chemical formula C5H3Cl3O3
Molecular mass 217.43 g/mol
CAS number [77439-76-0]
Density  ? g/cm3
Melting point  ? °C
SMILES O=C1OC(O)C(C(Cl)Cl)=C1Cl
Disclaimer and references

Mutagen X (MX), or 3-chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one, is a byproduct of the disinfection of water by chlorination. MX is produced by reaction of chlorine with natural humic acids.

Additional recommended knowledge

MX is found in chlorinated drinking water all over the world and is an environmental carcinogen that is known to cause several types of cancer in rats when present in large enough concentrations.[1] It is listed by the International Agency for Research on Cancer as a group 2B carcinogen meaning it is "possibly carcinogenic to humans". Although the concentration of MX in drinking water is typically 100- to 1000-fold lower than other common byproducts of water chlorination such as trihalomethanes, MX might play a role in the increased cancer risks that have been associated with the consumption of chlorinated water because of its potency in inducing DNA damage.[2]

References

  1. ^ Oxidative stress and DNA damage induced by a drinking-water chlorination disinfection byproduct 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in mice. Yuan, Jing; Liu, Hui; Zhou, Li-Hong; Zou, Ya-Lin; Lu, Wen-Qing. Mutation Research (2006), 609(2), 129-136.
  2. ^ Carcinogenicity of the chlorination disinfection by-product MX. McDonald, Thomas A.; Komulainen, Hannu. Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis & Ecotoxicology Reviews (2005), C23(2), 163-214.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mutagen_X". A list of authors is available in Wikipedia.
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