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Nalidixic acid

Nalidixic acid
Systematic (IUPAC) name
1-ethyl-7-methyl-4-oxo-[1,8]naphthyridine-3-carboxylic acid
CAS number 389-08-2
ATC code J01MB02
PubChem 4421
DrugBank APRD01133
Chemical data
Formula C12H12N2O3 
Mol. mass 232.235 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 90%
Metabolism Partially Hepatic
Half life 6-7 hours, significantly longer in renal impairment
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B U.S.

Legal status
Routes Oral

Nalidixic acid (tradenames Neggram® and Wintomylon®) is the basis for quinolone antibiotics.

Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts bacteriostatically (that is, it inhibits growth and reproduction). In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth.

It is especially used in treating urinary tract infections, caused for example by Escherichia coli, Proteus, Shigella, Enterobacter and Klebsiella.

See also

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nalidixic_acid". A list of authors is available in Wikipedia.
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