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Norfloxacin



Norfloxacin
Systematic (IUPAC) name
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-
3-carboxylic acid
Identifiers
CAS number 70458-96-7
ATC code J01MA06 S01AX12
PubChem 4539
DrugBank APRD00469
Chemical data
Formula C16H18FN3O3 
Mol. mass 319.331 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 3 to 4 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Norfloxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections.

Additional recommended knowledge

Mechanism of action

The mechanism of action of norfloxacin involves inhibition of the A subunit of bacterial DNA gyrase, an enzyme which is essential for DNA replication.[1]

References

  1. ^ Goldstein E (1987). "Norfloxacin, a fluoroquinolone antibacterial agent. Classification, mechanism of action, and in vitro activity". Am J Med 82 (6B): 3–17. PMID 3111257.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Norfloxacin". A list of authors is available in Wikipedia.
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