My watch list

Nitisinone


Nitisinone
Systematic (IUPAC) name
2-[2-nitro-4-(trifluoromethyl)benzoyl] cyclohexane-1,3-dione
Identifiers
CAS number	104206-65-7
ATC code	A16AX04
PubChem	115355
DrugBank	APRD01141
Chemical data
Formula	C₁₄H₁₀F₃N O₅
Mol. mass	329.228 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	Approximately 54 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin.

Product highlight

Precise electrochemical measurements in the smallest of spaces

Precisely determine water content - easier than ever before

High-precision ion chromatography made easy

v • d • e Other alimentary tract and metabolism products (A16)
Amino acids and derivatives	Levocarnitine - Ademetionine - Levoglutamide - Mercaptamine - Carglumic acid - Betaine
Enzymes	Alglucerase - Imiglucerase - Agalsidase alfa - Agalsidase beta - Laronidase - Sacrosidase - Alglucosidase alfa - Galsulfase - Idursulfase
Various alimentary tract and metabolism products	Tioctic acid - Anethole trithione - Sodium phenylbutyrate - Nitisinone - Zinc acetate - Miglustat