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Oritavancin (INN, also known as LY333328) is a novel semi-synthetic glycopeptide antibiotic being developed for the treatment of serious Gram-positive infections. Originally discovered and developed by Eli Lilly, oritavancin was acquired by InterMune in 2001 and then by Targanta Therapeutics in late 2005.
In Vitro Activity
Additional recommended knowledge
Oritavancin shares certain properties with other members of the glycopeptide class of antibiotics, which includes vancomycin, the current standard of care for serious Gram-positive infections in the United States and Europe. Data presented at the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in September 2007 demonstrated that oritavancin possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible Gram positive bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Enterococci, and Streptococci. Two posters presented at the meeting also demonstrated that oritavancin was more active than either metronidazole or vancomycin against strains of Clostridium difficile tested. In addition, research was conducted in partnership with the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) and presented at the American Society for Microbiology (ASM) 107th Annual General Meeting in May 2007, suggesting oritavancin’s potential utility as a therapy for exposure to Bacillus anthracis, the bacterium that causes anthrax, having demonstrated efficacy in a mouse model both pre- and post-exposure to the bacterium
Results have been presented but not yet published from two pivotal Phase 3 clinical trials testing the efficacy of oritavancin for the treatment of complicated skin and skin-structure infections (cSSSI) caused by Gram-positive bacteria. The primary endpoints of both studies were successfully met, with oritavancin achieving efficacy with fewer days of therapy than the comparator agents (vancomycin followed by cephalexin). In addition, oritavancin showed a significantly improved safety profile with a 19.2 percent relative reduction in the overall incidence of adverse events versus vancomycin/cephalexin (p<0.001) in the second and larger pivotal trial.
A Phase 2 clinical study is currently ongoing entitled “Single or Infrequent Doses for the Treatment of Complicated Skin and Skin Structure Infections (SIMPLIFI),” evaluating the efficacy and safety of either a single dose of oritavancin or an infrequent dose of oritavancin compared to the previously studied dosing regimen of 200mg oritavancin given once daily for 3 to 7 days.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Oritavancin". A list of authors is available in Wikipedia.|