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Additional recommended knowledge
The reaction of isatin with a base such as potassium hydroxide hydrolyses the amide bond to give the keto-acid 2. This intermediate can be isolated, but is typically not. A ketone (or aldehyde) will react with the aniline to give the imine (3) and the enamine (4). The enamine will cyclize and dehydrate to give the desired quiniline (5).
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pfitzinger_reaction". A list of authors is available in Wikipedia.|