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IUPAC name 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione
CAS number 144510-96-3
PubChem 134019
Molecular formula C17H19N5O2
Molar mass 325.365 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Pixantrone (rINN, codenamed BBR2778) is an immunosuppressant drug, an analogue of mitoxantrone with less toxic effects on cardiac tissue. It is being studied as an antineoplastic for different kinds of cancer, including solid tumors and hematological malignancies such as non-Hodgkin lymphomas.

It is also as potent as mitoxantrone in animal models of multiple sclerosis; however, results of human trials had not been published in 2007.[1]

As of 2007, several phase III clinical trials of pixantrone are underway.[2][3][4]


  1. ^ Gonsette RE, Dubois B (2004). "Pixantrone (BBR2778): a new immunosuppressant in multiple sclerosis with a low cardiotoxicity". J. Neurol. Sci. 223 (1): 81-6. doi:10.1016/j.jns.2004.04.024. PMID 15261566.
  2. ^ BBR 2778 for Relapsed, Aggressive Non-Hodgkin's Lymphoma (NHL). (2007-08-30). Retrieved on 2007-11-06.
  3. ^ Pixantrone or Other Chemotherapy Drugs in Treating Patients With Relapsed Non-Hodgkin's Lymphoma. (2007-10-25). Retrieved on 2007-11-06.
  4. ^ Fludarabine and Rituximab With or Without Pixantrone in Treating Patients With Relapsed or Refractory Indolent Non-Hodgkin Lymphoma. (2007-10-25). Retrieved on 2007-11-06.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pixantrone". A list of authors is available in Wikipedia.
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