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Proparacaine


Proparacaine
Systematic (IUPAC) name
2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate
Identifiers
CAS number	499-67-2
ATC code	N01BA04
PubChem	10367247
DrugBank	APRD00522
Chemical data
Formula	C₁₆H₂₆N₂O₃
Mol. mass	294.389 g/mol
Pharmacokinetic data
Bioavailability	n/a
Metabolism	plasma
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status
Routes	Topical

Proparacaine (Alcaine, Ak-Taine) is a topical anesthetic drug of the amino ester group. It is indicated for use as an ophthalmic anesthetic, to reduce pain and discomfort during procedures involving the eye. Proparacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. It is believed the drug exerts an effect on voltage gated sodium channels (as an antagonist) to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proparacaine are, however, unknown.

v • d • e Anesthetics: Local anesthetics (N01B)
Esters of aminobenzoic acid	Procaine, Tetracaine, Chloroprocaine, Benzocaine
Amides	Bupivacaine, Lidocaine, Mepivacaine, Prilocaine, Cinchocaine, Etidocaine, Articaine, Ropivacaine, Levobupivacaine
Esters of benzoic acid	Cocaine
Other	Hexylcaine, Iontocaine, Lidocaine/prilocaine