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The Reformatskii reaction (often spelled Reformatsky reaction) is an organic reaction which condenses aldehydes 1 (or ketones) with α-halo esters 2 with metallic zinc to form β-hydroxy-esters 3. It was discovered by Sergei Nikolaevich Reformatskii.
The organozinc reagent, also called a 'Reformatskii enolate', is prepared by treating an alpha-halo ester with zinc dust. Reformatskii enolates are less reactive than Grignard reagents and hence nucleophillic addition to the ester group does not occur.
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|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Reformatskii_reaction". A list of authors is available in Wikipedia.|