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Related to receptor tyrosine kinase



The related to receptor tyrosine kinases (RYKs) are a family of proteins that are a members of the receptor tyrosine kinase family of cell surface receptors.

Additional recommended knowledge

History

The gene encoding mouse RYK was first identified in 1992.[1] Subsequently cDNA encoding the RYK protein have been isolated from the following species.[2]

  • rat
  • chicken
  • Human
  • Zebrafish
  • Drosophila and
  • C. elegans

Structure

In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal extracellular ligand binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.[2]


References

  1. ^ Hovens, CM, Stacker, SA (1992). "RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs". Proc. Natl. Acad. Sci. USA. 89 (24): 11818-11822. PMID 1334548.
  2. ^ a b Halford, MM, and Stacker, S.A. (2001). "Revelations of the RYK receptor". Bioessays 23 (1): 34-45. PMID 11135307.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Related_to_receptor_tyrosine_kinase". A list of authors is available in Wikipedia.
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