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Additional recommended knowledge
Rhizoxin is biosynthesised by Burkholderia rhizoxina, an endosymbiotic bacteria of the fungus Rhizopus microsporus. It is one of a large group of rhizoxin-like compounds produced by the bacteria. The bacterial endosymbiote can be grown independently in culture. This may allow easy harvesting of rhizoxin and the related compounds avoiding total chemical synthesis, although total chemical synthesis is possible.
Rhizoxin binds beta tubulin in eukaryotic cells disrupting microtubule formation. This, in turn, prevents formation of the mitotic spindle inhibiting cell division. Additionally rhizoxin can depolymerise assembled microtubules. The function of rhizoxin is similar to Vinca alkaloids.
Rhizoxin has undergone clinical trials as an anti-cancer drug although, unfortunately, did not reach later stages of clinical trials due to low activity in vivo. Related compounds to rhizoxin may have improved biological activity.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Rhizoxin". A list of authors is available in Wikipedia.|