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Roxatidine



Roxatidine
Systematic (IUPAC) name
3-[3-(1-piperidylmethyl)phenoxy]propylcarbamoylmethyl acetate
Identifiers
CAS number 78628-28-1
ATC code A02BA06
PubChem 5105
Chemical data
Formula C19H28N2O4 
Mol. mass 348.437 g/mol
Pharmacokinetic data
Bioavailability 80–90%
Protein binding 5–7%
Metabolism Hepatic deacetylation
Minor involvement of CYP2D6 and CYP2A6
Half life 5–7 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes Oral

Roxatidine acetate is a specific and competitive H2 receptor antagonist. The antisecretory effect of roxatidine acetate is mediated by its main metabolite, roxatidine. Pharmacodynamic studies revealed that 150 mg of roxatidine acetate were optimal in suppressing gastric acid secretion, and that a single bedtime dose of 150 mg was more effective than a dose of 75 mg twice daily in terms of inhibiting nocturnal acid secretion.

Additional recommended knowledge

Roxatidine acetate has no antiandrogenic effects and does not influence drug-metabolizing enzymes in the liver.


 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Roxatidine". A list of authors is available in Wikipedia.
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