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Swain equation

The Swain equation relates the kinetic isotope effect for the proton/tritium combination with that of the proton/deuterium combination according to:

\frac{k_H}{k_T} =  \frac{k_H}{k_D}^{1.442}

where kH,D,T is the reaction rate constant for the protonated, deuterated and tritiated reactants.


  1. Use of Hydrogen Isotope Effects to Identify the Attacking Nucleophile in the Enolization of Ketones Catalyzed by Acetic Acid C. Gardner Swain, Edward C. Stivers, Joseph F. Reuwer, , Jr. Lawrence J. Schaad; J. Am. Chem. Soc.; 1958; 80(21); 5885-5893. First Page
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Swain_equation". A list of authors is available in Wikipedia.
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