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Additional recommended knowledge
It has been proposed that ThTP has a specific role in nerve excitability but this has never been confirmed and recent results suggest that ThTP probably plays a role in cell energy metabolism.  Moreover some results suggesting that ThTP deficiency is responsible for subacute necrotizing encephalopathy or Leigh's disease have not been confirmed. 
In E. coli, ThTP is accumulated in the presence of glucose during amino acid starvation.  On the other hand, suppression of the carbon source leads to the accumulation, of adenosine thiamine triphosphate (AThTP).
In mammals, ThTP is hydrolyzed by a specific thiamine triphosphatase.
Thiamine triphosphate (ThTP) was chemically synthesized in 1948 at a time when the only organic triphosphate known was ATP.
In all those studies, ThTP was separated from other thiamine derivatives using a paper chromatographic method, followed by oxidation in fluorescent thiochrome compounds with ferricyanide in alkaline solution.
This method is at best semi-quantitative, and the development of liquid chromatographic methods suggested that ThTP represents far less than 10 % of total thiamine in animal tissues and bacteria.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Thiamine_triphosphate". A list of authors is available in Wikipedia.|